ALDH2 Raw DNA Analysis & Clinical Evidence
Understand the ALDH2*2 deficiency and acetaldehyde clearance kinetics with clear ancestry frequency data.
Analyze your ALDH2 variants locally in your browser
Drop your raw 23andMe or AncestryDNA file into Verinome. It is parsed locally in your browser, so your raw file never uploads. To build the full report, only about 200 marker readouts (a few kilobytes, never your file and never your name) are checked. Educational and evidence-graded, not a diagnosis, bring anything clinical to your own clinician.
Published Evidence & Guideline Context for ALDH2
You have the fully-active form of the enzyme that breaks down acetaldehyde. Typically no alcohol-flush reaction from this gene.
Source: Brooks PJ et al., PLoS Med 2009;6:e50, PMID 19320537
One deficient copy: alcohol often causes facial flushing, rapid heartbeat and nausea because acetaldehyde builds up. Many carriers have low alcohol tolerance.
Source: Brooks PJ et al., PLoS Med 2009;6:e50, PMID 19320537
Two deficient copies: strong flushing and marked intolerance to alcohol. Educationally, heavy drinking despite flushing raises lifetime acetaldehyde exposure — an established carcinogen — so this is worth knowing.
Source: Brooks PJ et al., PLoS Med 2009;6:e50, PMID 19320537