CYP2C19 Raw DNA Analysis & Clinical Evidence
CPIC Level 1A pharmacogenomic interpretation for CYP2C19 clopidogrel bioactivation. Evidence grade A, parsed 100% in your browser.
Analyze your CYP2C19 variants locally in your browser
Drop your raw 23andMe or AncestryDNA file into Verinome. It is parsed locally in your browser, so your raw file never uploads. To build the full report, only about 200 marker readouts (a few kilobytes, never your file and never your name) are checked. Educational and evidence-graded, not a diagnosis, bring anything clinical to your own clinician.
Published Evidence & Guideline Context for CYP2C19
You don't carry the common *2 non-working version of CYP2C19 at this spot.
Source: CPIC clopidogrel/CYP2C19 guideline (Scott et al., Clin Pharmacol Ther 2013, PMID 23698643); PharmGKB CYP2C19
You carry one copy of the common *2 non-working version, which slows CYP2C19 somewhat (intermediate metabolizer if your other CYP2C19 markers are normal). This matters most for the blood-thinner clopidogrel and some antidepressants and acid-reducers.
Source: CPIC clopidogrel/CYP2C19 guideline (Scott et al. 2013, PMID 23698643); CPIC SSRI guideline (Hicks/Bousman et al., PMID 25974703); CPIC PPI/CYP2C19 guideline (Lima et al. 2021, PMID 32770672); PharmGKB
You carry two copies of the *2 non-working version, so CYP2C19 works poorly (poor metabolizer). This is the group where the blood-thinner clopidogrel may not work well, and several antidepressants/antifungals build up more.
Source: CPIC clopidogrel/CYP2C19 guideline (Scott et al. 2013, PMID 23698643); CPIC voriconazole guideline (Moriyama et al. 2017, PMID 27981572); CPIC PPI guideline (Lima et al. 2021, PMID 32770672); PharmGKB
You don't carry the *3 non-working version (most relevant for people of East Asian ancestry).
Source: CPIC clopidogrel/CYP2C19 guideline (Scott et al. 2013, PMID 23698643); PharmGKB CYP2C19
You carry one copy of the *3 non-working version, which slows CYP2C19 (intermediate metabolizer if your other markers are normal). If you also carry a *2 copy, the two together make you a poor metabolizer.
Source: CPIC clopidogrel/CYP2C19 guideline (Scott et al. 2013, PMID 23698643); CPIC SSRI guideline (PMID 25974703); PharmGKB
You carry two copies of the *3 non-working version, so CYP2C19 works poorly (poor metabolizer). Same practical meaning as two *2 copies.
Source: CPIC clopidogrel/CYP2C19 guideline (Scott et al. 2013, PMID 23698643); CPIC voriconazole guideline (Moriyama et al. 2017, PMID 27981572); PharmGKB
You don't carry the *17 fast version of CYP2C19 at this spot.
Source: CPIC clopidogrel/CYP2C19 guideline (Scott et al. 2013, PMID 23698643); PharmGKB CYP2C19
You carry one copy of the *17 fast version, which speeds CYP2C19 up (rapid metabolizer if your other markers are normal). Some CYP2C19 drugs may clear a bit faster.
Source: CPIC voriconazole guideline (Moriyama et al. 2017, PMID 27981572); CPIC PPI guideline (Lima et al. 2021, PMID 32770672); PharmGKB CYP2C19
You carry two copies of the *17 fast version, so CYP2C19 is very active (ultrarapid metabolizer). Some antifungals/acid-reducers may clear too fast to reach normal levels at a standard dose.
Source: CPIC voriconazole guideline (Moriyama et al. 2017, PMID 27981572); CPIC PPI guideline (Lima et al. 2021, PMID 32770672); CPIC SSRI guideline (PMID 25974703); PharmGKB