MTHFR Raw DNA Analysis & Clinical Evidence
Analyze your MTHFR C677T and A1298C variants locally in your browser. Honest evidence grading, ACMG clinical context, and zero cloud uploads.
Analyze your MTHFR variants locally in your browser
Drop your raw 23andMe or AncestryDNA file into Verinome. It is parsed locally in your browser, so your raw file never uploads. To build the full report, only about 200 marker readouts (a few kilobytes, never your file and never your name) are checked. Educational and evidence-graded, not a diagnosis, bring anything clinical to your own clinician.
Published Evidence & Guideline Context for MTHFR
The common, fully-functional version. Nothing to act on here.
Source: Hickey SE, Curry CJ, Toriello HV. ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing. Genet Med. 2013;15(2):153-156. PMID: 23288205.
One copy of the 'slow' variant. In practice this makes little to no difference. Major medical societies advise against acting on it.
Source: Hickey SE et al. ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing. Genet Med. 2013;15(2):153-156. PMID: 23288205.
Two copies of the 'slow' variant. It can nudge homocysteine up a little, mostly if your folate is low — and eating enough folate covers it. This is a low-value marker; guidelines say routine MTHFR testing isn't recommended. Educational only, not a diagnosis.
Source: Hickey SE, Curry CJ, Toriello HV. ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing. Genet Med. 2013;15(2):153-156. PMID: 23288205. See also PharmGKB clinical annotation for rs1801133.
The common version at this second MTHFR spot. Nothing to act on.
Source: Hickey SE et al. ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing. Genet Med. 2013;15(2):153-156. PMID: 23288205.
One copy of the 1298 variant. On its own it does essentially nothing measurable.
Source: Hickey SE et al. ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing. Genet Med. 2013;15(2):153-156. PMID: 23288205.
Two copies of the 1298 variant. This one doesn't raise homocysteine by itself and isn't clinically actionable. A low-value marker included for transparency. Educational only.
Source: Hickey SE, Curry CJ, Toriello HV. ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing. Genet Med. 2013;15(2):153-156. PMID: 23288205.