SLCO1B1 Raw DNA Analysis & Clinical Evidence
Check your SLCO1B1 statin uptake transporter status (CPIC Level 1A) to assess statin-induced myopathy risk in browser memory.
Analyze your SLCO1B1 variants locally in your browser
Drop your raw 23andMe or AncestryDNA file into Verinome. It is parsed locally in your browser, so your raw file never uploads. To build the full report, only about 200 marker readouts (a few kilobytes, never your file and never your name) are checked. Educational and evidence-graded, not a diagnosis, bring anything clinical to your own clinician.
Published Evidence & Guideline Context for SLCO1B1
Two normal copies of the SLCO1B1 statin-transporter gene. At this marker your genetics do not raise the odds of statin-related muscle side effects.
Source: CPIC SLCO1B1/ABCG2/CYP2C9 & statin-associated musculoskeletal symptoms guideline, Cooper-DeHoff 2022, PMID 35152405; PharmGKB level 1A.
One reduced-function copy. Simvastatin especially can build up somewhat more, modestly raising the chance of muscle aches. Other statins are affected less. Educational only.
Source: CPIC statin/SLCO1B1 guideline, Cooper-DeHoff 2022, PMID 35152405; PharmGKB level 1A (simvastatin).
Two reduced-function copies. Higher chance of statin muscle side effects, especially with simvastatin at higher doses. This is educational — any statin choice or dose is a conversation for your clinician.
Source: CPIC statin/SLCO1B1 guideline, Cooper-DeHoff 2022, PMID 35152405; PharmGKB level 1A.