GENE · ACTN3

ACTN3 Raw DNA Analysis & Clinical Evidence

Analyze ACTN3 fast-twitch muscle alpha-actinin-3 expression from raw 23andMe/AncestryDNA files with zero cloud egress.

Analyze your ACTN3 variants locally in your browser

Drop your raw 23andMe or AncestryDNA file into Verinome. It is parsed locally in your browser, so your raw file never uploads. To build the full report, only about 200 marker readouts (a few kilobytes, never your file and never your name) are checked. Educational and evidence-graded, not a diagnosis, bring anything clinical to your own clinician.

Analyze My ACTN3 Data → How our A–D grading works →

Published Evidence & Guideline Context for ACTN3

rs1815739 · NUTRITION

Grade C Genotype CC:

You make the fast-twitch muscle protein alpha-actinin-3. Slightly more common in sprint/power athletes. It does NOT determine your fitness.

Source: Yang N et al., Am J Hum Genet 2003, PMID:12879365

Grade C Genotype CT:

You make alpha-actinin-3 (one working copy). No strong lean either way.

Source: Yang N et al., Am J Hum Genet 2003, PMID:12879365

Grade C Genotype TT:

You make no alpha-actinin-3 in muscle (totally normal, ~1 in 6 people). Statistically a hair more common in endurance athletes, but this does not decide whether you're better at sprinting or endurance.

Source: Yang N et al., Am J Hum Genet 2003, PMID:12879365