GENE · COMT

COMT Raw DNA Analysis & Clinical Evidence

Honest, de-hyped analysis of COMT rs4680 dopamine clearance. Clear Grade D labeling of popular myths vs replicated science.

Analyze your COMT variants locally in your browser

Drop your raw 23andMe or AncestryDNA file into Verinome. It is parsed locally in your browser, so your raw file never uploads. To build the full report, only about 200 marker readouts (a few kilobytes, never your file and never your name) are checked. Educational and evidence-graded, not a diagnosis, bring anything clinical to your own clinician.

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Published Evidence & Guideline Context for COMT

rs4680 · TRAIT

Grade C Genotype AA:

You have the lower-activity 'Met/Met' version of COMT. On average this links to slightly higher pain and stress sensitivity, but real-world effects are small and easily outweighed by environment.

Source: PMID 12595695 (Zubieta 2003 Science)

Grade C Genotype AG:

You have one copy each - intermediate dopamine-clearing activity.

Source: PMID 12595695 (Zubieta 2003 Science)

Grade C Genotype GG:

You have the higher-activity 'Val/Val' COMT version, on average slightly less pain-sensitive. The effect is small.

Source: PMID 12595695 (Zubieta 2003 Science)