CYP2D6 Raw DNA Analysis & Clinical Evidence
Analyze CYP2D6 metabolizer status for opioids, antidepressants, and tamoxifen. Grade A CPIC evidence guidelines.
Analyze your CYP2D6 variants locally in your browser
Drop your raw 23andMe or AncestryDNA file into Verinome. It is parsed locally in your browser, so your raw file never uploads. To build the full report, only about 200 marker readouts (a few kilobytes, never your file and never your name) are checked. Educational and evidence-graded, not a diagnosis, bring anything clinical to your own clinician.
Published Evidence & Guideline Context for CYP2D6
You do not carry the common *4 'off-switch' variant here, but this test cannot see every CYP2D6 change.
Source: CPIC Guideline for CYP2D6 and opioids (Crews et al., Clin Pharmacol Ther 2021, PMID 33387367); PharmGKB CYP2D6*4 / rs3892097
You carry one copy of the *4 no-function variant; combined with a working copy this often means somewhat reduced CYP2D6 activity.
Source: CPIC Guideline for CYP2D6 and opioids (Crews et al. 2021, PMID 33387367); PharmGKB CYP2D6*4 / rs3892097
Two no-function copies point to a 'poor metabolizer' pattern for several common medications.
Source: CPIC Guideline for CYP2D6 and opioids (Crews et al. 2021, PMID 33387367); CPIC/PharmGKB CYP2D6 diplotype-to-phenotype tables
You do not carry the P34S variant that usually marks the reduced-function *10 allele.
Source: CPIC CYP2D6 diplotype tables; PharmGKB CYP2D6*10 / rs1065852; PMID 15709114 (tamoxifen/*10)
You carry one copy of the P34S variant, typically the reduced-function *10 allele (but it can also travel with *4).
Source: CPIC CYP2D6; PharmGKB CYP2D6*10 / rs1065852
Two copies of the P34S variant usually mean reduced CYP2D6 activity (intermediate metabolizer), common in East Asian ancestry.
Source: CPIC CYP2D6 diplotype-to-phenotype tables; PharmGKB CYP2D6*10 / rs1065852
You do not carry the *41 reduced-function variant at this position.
Source: CPIC CYP2D6 diplotype tables; PharmGKB CYP2D6*41 / rs28371725
You carry one copy of the *41 reduced-function variant.
Source: CPIC CYP2D6; PharmGKB CYP2D6*41 / rs28371725
Two copies of the *41 reduced-function variant suggest reduced (intermediate) CYP2D6 activity.
Source: CPIC CYP2D6 diplotype-to-phenotype tables; PharmGKB CYP2D6*41 / rs28371725
You do not carry the variant that marks the *17 reduced-function allele (most relevant in African ancestry).
Source: CPIC CYP2D6 diplotype tables; PharmGKB CYP2D6*17 / rs28371706
You carry one copy of the *17 reduced-function marker (mainly seen in African ancestry).
Source: CPIC CYP2D6; PharmGKB CYP2D6*17 / rs28371706
Two copies of the *17 reduced-function marker suggest reduced CYP2D6 activity.
Source: CPIC CYP2D6 diplotype-to-phenotype tables; PharmGKB CYP2D6*17 / rs28371706
You do not carry the 296Cys variant, a marker used mainly to help identify CYP2D6 star alleles.
Source: PharmGKB CYP2D6*2 / rs16947; CPIC CYP2D6 allele-definition tables
You carry one copy of a common CYP2D6 marker (296Cys); on its own it does not determine your metabolizer status.
Source: PharmGKB CYP2D6*2 / rs16947; CPIC CYP2D6 allele-definition tables
Two copies of the 296Cys marker; interpretation depends on the other CYP2D6 variants, not this one alone.
Source: PharmGKB CYP2D6*2 / rs16947; CPIC CYP2D6 allele-definition tables
You do not carry the 486Thr tag; this position is a phasing marker, not a function change by itself.
Source: PharmGKB CYP2D6 rs1135840 (S486T); CPIC CYP2D6 allele-definition tables
You carry one copy of the 486Thr tag; on its own it says nothing about your CYP2D6 activity.
Source: PharmGKB CYP2D6 rs1135840 (S486T); CPIC CYP2D6 allele-definition tables
Two copies of the 486Thr tag; a phasing marker only, not a metabolizer result.
Source: PharmGKB CYP2D6 rs1135840 (S486T); CPIC CYP2D6 allele-definition tables
*6 is a known 'off' variant, but it is a deletion this test format can't read, so we can't score it from your file.
Source: CPIC CYP2D6 allele functionality table; PharmGKB CYP2D6*6 / rs5030655 (indel, not array-matchable here)