GENE · HFE

HFE Raw DNA Analysis & Clinical Evidence

Check hereditary hemochromatosis variants C282Y and H63D in browser RAM with ACMG clinical context.

Analyze your HFE variants locally in your browser

Drop your raw 23andMe or AncestryDNA file into Verinome. It is parsed locally in your browser, so your raw file never uploads. To build the full report, only about 200 marker readouts (a few kilobytes, never your file and never your name) are checked. Educational and evidence-graded, not a diagnosis, bring anything clinical to your own clinician.

Analyze My HFE Data → How our A–D grading works →

Published Evidence & Guideline Context for HFE

rs1800562 · CARRIER
Grade A Genotype GG:

You do not carry the main hereditary hemochromatosis variant (C282Y). This test only looks at specific spots, so it cannot rule out every cause of iron overload.

Source: ClinVar rs1800562 (pathogenic, HFE-related hemochromatosis); Feder et al. 1996, Nat Genet PMID 8696333

Grade A Genotype AG:

You carry one copy of the main hemochromatosis variant. Single-copy carriers usually do not develop iron overload on their own, though combining it with the H63D variant can nudge iron levels up.

Source: ClinVar rs1800562 (pathogenic); Feder et al. 1996, Nat Genet PMID 8696333

Grade A Genotype AA:

You have two copies of the main hemochromatosis variant, the most common inherited cause of iron overload. Many people with this genotype never develop problems, but it is worth discussing simple iron blood tests with a doctor.

Source: ClinVar rs1800562 (pathogenic); Feder et al. 1996, Nat Genet PMID 8696333

rs1799945 · CARRIER
Grade B Genotype CC:

You do not carry the milder hemochromatosis variant (H63D).

Source: ClinVar rs1799945 (conflicting/risk factor, low penetrance); Feder et al. 1996, Nat Genet PMID 8696333

Grade B Genotype CG:

You carry one copy of the milder H63D variant. On its own it usually does little, but paired with one copy of the main C282Y variant it can slightly raise iron levels.

Source: ClinVar rs1799945 (low-penetrance risk factor); European Molecular Genetics Quality Network / EASL guidance; Feder et al. 1996 PMID 8696333

Grade B Genotype GG:

You have two copies of the milder H63D variant. This is a weak risk factor and most people with it have normal iron levels; clinically significant iron overload from H63D alone is uncommon.

Source: ClinVar rs1799945 (low-penetrance risk factor); Feder et al. 1996 PMID 8696333