GENE · VKORC1

VKORC1 Raw DNA Analysis & Clinical Evidence

CPIC Level 1A warfarin sensitivity guidelines and dosage kinetics from your raw DNA file. Zero bytes uploaded.

Analyze your VKORC1 variants locally in your browser

Drop your raw 23andMe or AncestryDNA file into Verinome. It is parsed locally in your browser, so your raw file never uploads. To build the full report, only about 200 marker readouts (a few kilobytes, never your file and never your name) are checked. Educational and evidence-graded, not a diagnosis, bring anything clinical to your own clinician.

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Published Evidence & Guideline Context for VKORC1

rs9923231 · PGX

Grade A Genotype CC:

For this warfarin gene you have the version linked to needing a relatively higher warfarin dose. This does not affect other drugs.

Source: CPIC Warfarin Guideline (PMID 28198005); Rieder et al. 2005 (PMID 15930419); PharmGKB VKORC1 rs9923231.

Grade A Genotype CT:

For this warfarin gene you carry one copy of the lower-dose version. It is used to help estimate a warfarin starting dose.

Source: CPIC Warfarin Guideline (PMID 28198005); IWPC (Klein et al. 2009, PMID 19228618).

Grade A Genotype TT:

For this warfarin gene you have two copies of the version linked to needing a lower warfarin dose and being more sensitive to it. This does not change other drugs.

Source: CPIC Warfarin Guideline (PMID 28198005); Rieder et al. 2005 (PMID 15930419); PharmGKB VKORC1 rs9923231.